摘要
对１６例先天性心脏病合并肺动脉高压病人进行手术中肺组织活检，将形态学变化与术前心导管资料对比，发现肺血管阻力与肺组织胶原纤维含量呈正相关，而与血管腔相对面积呈负相关。小血管肌型化、内皮轻度增生及肌性动脉中层增厚为早、中期病变，而丛样病变和阻塞性内膜增生为晚期病变。并对各种病变的意义和发生机制进行了探讨。
Lung biopsies were made at the time of surgery in 16 patients with congenital heart defects associated with pulmonary hypertension.The pathological changes were observed and analyzed in comparison with pre-operative hemodynamic data.It was found that pulmonary vascular resistance correlated positively with lung collagen content and negatively with the area of the muscular pulmonary arteries.Muscular extension into arterioles,cellular intimal hyperplasia and medial thickening are early and intermediate changes,whereas plexiform lesions and occlusive intimal flbrosis are late ones.Pathological mechanisme of the lesions and their implieation to hemodynamic abnormalities are described.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1994年第4期299-301,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
肺动脉高压
血液动力学
病理学
超微结构
Congenital heart disease
Pulmonary hypertension
Pathology
Ultrastuctural pathology
