摘要
目的探讨卡托普利对接振家兔神经功能的影响及意义。方法将家兔分为接振组、干预组和对照组,对接振组和干预组进行接振试验,干预组从接振第11天起给予卡托普利。于接振试验前后对各组家兔进行体感诱发电位(SEP)及坐骨神经运动传导功能(MCF)的测定。结果接振组N1波、P1波、N2波的潜伏期分别为(30.76±4.26)、(41.91±6.67)、(45.29±5.81)ms,干预组分别为(27.00±3.04)、(35.07±4.20)、(41.15±3.19)ms。与接振试验前及试验后干预组、对照组比较,接振组SEP各波潜伏时明显延长,差异有统计学意义(P<0.05,P<0.01)。接振组坐骨神经运动传导速度、远端波幅、远端潜伏时分别为(35.69±4.37)ms、(1.55±0.73)μV、(8.16±0.71)ms,干预组分别为(52.20±5.13)ms、(2.89±0.36)μV、(7.26±0.77)ms。干预组较接振组坐骨神经运动传导速度、远端波幅明显延长,远端潜伏时均明显减小,差异均有统计学意义(P<0.01)。结论卡托普利对接振家兔神经功能的损伤有一定的改善作用。
Objective To study the effect of captopril on the nervous function in rabbits exposed to vibration. Methods Rabbits were divided into vibration group,intervention group,and control group.Vibration group and intervention group were exposed to(tested by) vibration.Captopril was given to intervention group from the 11th day of vibration exposure.Somatosensory evoked potential(SEP) and motor nervous conduction function(MCF) were measured and analyzed in each group before and after vibration exposure. Results The latent periods of N1,P1 and N2 of SEP in vibration group after vibration exposure were (30.76±4.26),(41.91±6.67),and (45.29±5.81)ms respectively,and in intervention group after vibration exposure were (27.00±3.04),(35.07±4.20) and (41.15±3.19)ms respectively.Compared with intervention group before and after exposure,and control group,the latent periods of each wave of SEP were delayed significantly(P<0.05).The nervous conduction velocity,the distant wave amplitude,and the distant potential period of sciatic nerve in vibration group after vibration exposure were significantly different from those in intervention group[(35.69±4.37)m/s,(1.55±0.73)μV,(8.16± 0.71)ms respectively vs (52.20±5.13)m/s,(2.89±0.36)μV,(7.26± 0.77)ms respectively(P<0.01)]. Conclusion Captopril may improve the impairment of nervous functions to a certain degree in rabbits exposed to vibration.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2005年第3期175-177,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
山东省自然基金资助项目(Y2002c20)
