摘要
目的探讨L 精氨酸对后肢接振家兔外周血管功能的保护作用及意义。方法将家兔随机分为单纯接振组 (A组 ) ,L 精氨酸组 (B组 )和对照组 (C组 ) ,并进行接振试验。从试验第 11天起 ,每隔 2d给予B组L 精氨酸 2 0mg/kg ,分别测定各组血浆一氧化氮 (NO)、内皮素 (ET)浓度进行测定分析。结果试验前及试验后第 10天、2 0天、3 0天 ,A组NO浓度分别为 ( 172 .40 0± 12 .3 5 0 ) μmol/L、( 167.915± 7.879) μmol/L、( 15 0 .0 88± 7.45 3 ) μmol/L、( 13 2 .3 13± 8.747) μmol/L ,ET浓度分别为 ( 4 3 .5 75±8.166) μg/L、( 4 6.2 13± 5 .44 8) μg/L、( 5 3 .788± 6.0 3 7) μg/L、( 66.613± 9.485 ) μg/L ;B组浓度分别为 ( 172 .85 0± 13 .3 2 3 ) μmol/L、( 167.788± 10 .5 3 1) μmol/L、( 164 .12 5± 8.3 80 ) μmol/L、( 161.813± 7.63 9) μmol/L ,ET浓度分别为 ( 4 3 .5 13± 4.90 1) μg/L、( 4 7.175± 7.481) μg/L、( 4 7.0 2 5± 5 .0 2 6) μg/L、( 4 7.60 0± 4.883 ) μg/L。随接振时间延长 ,A组NO浓度有明显降低、ET浓度有明显升高趋势 (P <0 .0 1) ;B组也有类似变化 ,但变化幅度较小。结论L 精氨酸可通过影响接振家兔血管内皮活性物质而保护外周血管功能。
Objective To explore the effects of L- Arginine on vascular endothelial substance in vibrated rabbits. Methods Rabbits were divided into three group randomly. Group A was as pure-exposed vibration;group B was as L- Arginine intervention group. The plasma concentration of nitric oxide(NO) and endothelin(ET) were measured in each group before and after the experiment. Results Before the experiment and the 10th day ,the 20th day and the 30th day after the experiment,the plasma concentration of NO in group A was (172.400±12.350)μmol/L,(167.915±7.879)μmol/L,(150.088±7.453)μmol/L and(132.313±8.747)μmol/L respectively,and the plasma concentration of ET was (43.575±8.166)μg/L,(46.213±5.448)μg/L,(53.788±6.037)μg/L and(66.613±9.485)μg/L respectively;the plasma concentration of NO in group B was (172.850±13.323)μmol/L,(167.788±10.531)μmol/L,(164.125±8.380)μmol/L and(161.813±7.639)μmol/L respectively,and the plasma concentration of ET was (43.513±4.901)μg/L,(47.175±7.481)μg/L,(47.025±5.026)μg/L,(47.600±4.883)μg/L respectively. Those showed that NO concentration in group A had a significantly decreasing trend, whereas ET concentration had a significantly increasing trend (P<0.05,P< 0.01). Concentration of NO and ET in group B had a less change.Conclusion L-Arginine could protect the vascular functions by affecting the concentration of vascular endothelial active substance.
出处
《中国行为医学科学》
CSCD
2004年第5期486-487,共2页
Chinese Journal of Behavioral Medical Science
基金
山东省自然科学基金资助 (项目号 :Y2 0 0 2c2 0 )
