摘要
女性乳腺癌４０例，良性肿瘤３７例，乳腺增生病５２例用ＡＢＣ法做了免疫组化Ｐ２１蛋白水平检测，其阳性率分别是７２．５％，３２．４％，２３．１％。阳性表达主要在分化差的浸润性导管癌细胞；乳腺增生病中５例导管上皮细胞不典型增生有３例阳性表达，提示Ｐ２１蛋白检测可为估价乳腺组织癌变和病变预后提供分子生物学依据。
he level of P21 protein in 40 breast carcinomas,37 benign tumors and 52 proliferative breast diseases in females were determined by the ABC immunohistochemical method.The positive rate was 72.5%,32.43%and 23. 07%respectively.The positive expressions were mainly fotlnd in tumor cells in poorly differentiated infiltrating ductal carcinomas and in 3 of the 5 proliferative breast disease cases with atypical hyperplasia of ductal epithelium, suggesting that P21 protein detection could provide a molecular biological basis for the evaluation of malignant changes and the prognosis of mammary lesions.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1994年第5期302-303,共2页
Chinese Journal of Pathology
关键词
乳腺癌
癌基因
蛋白
P21
Breast neoplasms Hyperplasia Oncogene protein
