摘要
建立了HPLC-ELSD法测定盐酸多柔比星脂质体注射液磷脂膜中胆固醇、磷脂酰胆碱和溶血磷脂酰胆碱的含量,采用氨基色谱柱,流动相为2%草酸-乙醇-甲醇-氯仿(16∶84∶97∶3),流速1ml/min。三者的平均回收率分别为98.8%、98.7%、98.6%,RSD为1.3%、0.9%、1.4%。
A HPLC-ELSD method was established for determination of cholesterin, phosphatidylcholine and lysophosphatidyl choline in phospholipid bilayer of doxorubicin hydrochloride liposomes for injection. A NH2 column was used with the mobile phase of 2% oxalic acid-ethanol-methanol-chloroform (16∶84∶97∶3) at the flow rate of 1ml/min. The average recoveries were 98.8%、98.7%、98.6%, with RSD of 1.3%, 0.9% and 1.4%, respectively.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第6期359-361,共3页
Chinese Journal of Pharmaceuticals
