摘要
为探索直肠癌术前氟尿嘧啶（５－ＦＵ）辅助化疗更合理的给药途径，作者应用同位素￣（１４）Ｃ标记的５－ＦＵ栓剂，经直肠腔内给药，进行了组织浓度和分布的测定。结果发现经直肠腔给药后，癌组织和肠系膜淋巴结的５－ＦＵ浓度较高，比传统的静脉给药为高，且持续时间较长，这将有利于破坏癌灶和淋巴结中的癌细胞，防止直肠癌复发和扩散。提示直肠癌术前采用５－ＦＵ辅助化疗，可减少Ｄｕｋｅｓ’Ｂ和Ｃ期术后复发，提高生存率。
More reasonable route of administration of 5-FU in rectal cancer therapy,￣(14)C-tagged 5-FU suppository intrarectal administration was studied experimentally。 The distributionand concentration of 5-FU in tissues showed that a much higher concentration in cancer cell andmesenteric lymph nodes after using suppository other than iv 5-FU. The suppository 5-FU lastedlonger time would be profitable to destroy cancer cells in the tumor and reginal lymph nodes , andcould prevent from recurrence and metastasis. 5-FU suppository used before operation for rectalcancer could decrease therecurrence of Dukes’B and C rectal cancers.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1994年第7期433-435,共3页
Chinese Pharmaceutical Journal
