摘要
目的探讨血清胆红素(BIL)与冠心病(CHD)的关系。方法将400例患者按冠状动脉造影结果分为CHD组(240例)和对照组(160例)。用日立737全自动生化分析仪检测清晨空腹静脉血清总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)及高、低密度脂蛋白胆固醇浓度(HDLC、LDLC),比较两组间的临床特征及实验室指标的差异,并对血清胆红素水平与CHD之间的关系进行单因素及多元逐步Logistic回归分析。结果CHD组血清TBIL、DBIL、IBIL和HDLC水平较低,LDLC水平较高,与对照组比较有显著差异性(P<0.01)。单因素分析显示血清胆红素浓度越低,CHD发病率越高(P<0.01),多元逐步Logistic回归分析发现,血清胆红素浓度与CHD的发生显著负相关(χ2=26.2329,P=0.0001,OR=0.952)。结论提示血清胆红素低水平可作为CHD的一个新的独立危险因子,其机制可能是影响脂类代谢。
Objective To investigate the relationship between serum bilirubin (BIL) and coronary heart disease (CHD). Methods 400 cases were divided into the CHD group and the control group according to the results of coronary arteriography. Hitachi 737 automatic biochemical Analyzer was used to detect the venous serum total bilirubin(TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), and high, low density lipoprotein concentration (HDL-C, LDL-C) with the stomach empty in the early morning, to compare the clinical features and the difference of laboratory index among the two groups. and also analyze regressively the relationship between serum bilirubin level and CHD of single factor and multiple factors by Logistic. Result The level of serum TBIL, DBIL, IBIL and HDL-C was relatively lower . And that of LDL-C was relatively higher in the CHD group. There was significant difference (P<0.01). Gradual multiple-factor Logistic regressive analysis showed that there was apparent negative correlation between serum BIL concentration and the incidence of CHD (χ 2=26.2329,P=0.0001,OR=0.952). Conclusion It is suggested that the low level of serum bilirubin be used as a new independent dangerous factor of CHD, whose mechanism could affect lipid metabolism.
出处
《河南科技大学学报（医学版）》
2005年第2期127-129,共3页
Journal of Henan University of Science & Technology:Medical Science
关键词
冠心病
胆红素
危险因子
coronary heart disease
bilirubin
dangerous factor
