摘要
用免疫组织化学方法观察大鼠青霉素致痛及加电针后脑内强啡肽。及亮啡肽的变化。致痫时,在海马门区及苔样纤维上强啡肽含量明显减少,在海马下脚、CA_1区等结构内亮啡肽含量明显增加,电针后海马中强啡肽含量增加,亮啡肽含量在上述各区显著减少。提示:癫痫及电针抗痫可能与脑内强啡肽和亮啡肽的变化有关。
Immunocytochemical technics were used to evaluate the influence of penicillin-induced seizure and electroacupuncture treatment on dynorphin1-8 and leu-enkephalin immunoreactivity in hippocampus. It was found that 3 h after beginning of seizure there started a dramatic decrease in dynorphin1-8 in hilus, mossy fiber of hippocampus but an increase in hilus, mossy fiber of hippocampus but an increase in leu-enkephalin in subicu-lum, CA1 area of hippocampus and some other limbic structures. Electroacupuncture treatment decreased the leu-enkephalin immunoreactivity in the nuclei mentioned above and increased dynorphin1-8 immunoreactivity in hippocampus. The results show that epilepti-form activity and electroacupuncture inhibitory effect on seizure may be related to the alteration of dynorphin1-8 and leu-enkephalin in the brain.
出处
《中国药理学报》
CSCD
1994年第2期155-157,共3页
Acta Pharmacologica Sinica
基金
Project supported by the National Natural Science Foundation of China
№ 39170897.
关键词
强啡肽
亮啡肽
海马
电针
免疫组化
dynorphin
leucine enkephalin
seizures
hippocampus
immunohisto - chemistry
electroacupuncture
