摘要
用^(131)I按氯胺T法标记眼镜蛇毒细胞毒素14,观察其在大鼠体内的分布,静脉给药后0.5h,分布最多的是肾,每mg组织放射性达5979dpm,为对照组的14倍,肝、脾、胰、肾上腺亦有较高分布,给药后2h,脑组织亦见分布,其每mg组织放射性为50dpm,是对照组的3倍。
Cytotqxin 14 (CT14) from Naja naja atra venom was labelled with 3 I by chloramine-T method and its tissue distribution was studied in rats. The highest concentration of the cytotoxin was found in kidney, 5979 dpm per mg weight, 14 times more than that of the control animals, at 0. 5 h after iv injection and high concentrations were found in liver, spleen, pancreas, and adrenal. CT14 was also found in brain at 2 h after injection, 50 dpm per mg weight, 3 times more than that of the control.
出处
《中国药理学报》
CSCD
1994年第1期90-92,共3页
Acta Pharmacologica Sinica
关键词
眼镜蛇毒
蛇毒
细胞毒素
碘131
cobra venoms
cytotoxins
iodine radioisotopes
tissue distribution
