摘要
对硫酸呈色－分光光度法测定红霉素片溶出度含量进行了研究。结果表明，呈色液色泽的深浅，可从分光光度计４９０ｎｍ波长处测定的吸收度，反映出溶出药含量之变化，符合Ｂｅｅｒ定律。线性范围为３０～１２４ｕ／ｍｌ，ｙ＝０．３８２９＋０．０３２９．ｒ＝０．９９９９，Ｐ＜０．０１，回收率ＲＳＤ为９９．４％±０．０４４％。与已报道的其它方法相比，本法具有无需萃取、不受辅料干扰、操作简便以及重现性好等优点。
A method for quantitative analysis of erythromycin tablet dissolved in simulated intestinal juice was described. In the experiment,the sample extraction could be omitted,so the filtered portion of the solution under test could be treated directly with concentrated sulfuric acid to develop the color and detected the wavelength of absorbance at 490 nm. The proposed method is simple and rapid,and its result is accurate and reproducible.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1994年第1期18-19,共2页
Journal of China Pharmaceutical University
基金
1995版中华人民共和国药典列题研究项目
关键词
红霉素
溶出度
含量测定
Erythromycin tablet
Color development reaction
Sulfuric acid
Dissolution
Quantitative analysis
Spectrophotometry
