摘要
目的:探讨宽叶缬草提取物(VOL)对戊四氮(PTZ)致癫大鼠模型的脑电和行为变化的影响。方法:用PTZ37.5mg/kg腹腔注射Wistar大鼠28天建立慢性癫模型,同时胃管分组给予VOL500mg/kg、1000mg/kg、1500mg/kg,每天三次,观察大鼠行为及脑电变化。结果:PTZ致癫大鼠在28天时87%为重度发作,脑电发作潜伏期及波密度分别为4.01±1.70min,145.75±19.84个/min,应用三种不同剂量的VOL治疗三周后大鼠癫发作程度明显减轻,脑电发作潜伏期延长,分别为7.36±2.18min、9.42±2.05min、11.19±1.95min,波密度减少与PTZ模型对照组比较,P<0.05;且高剂量组更明显。结论:VOL能有效对抗PTZ的点燃作用,且有剂量依赖性,在第3周时才开始显效。
Objective:To investigate the effects of Valeriana officinalis Var.latifolia(VOL) on behaviors and EEG of rats with epilepsy induced by pentylenetetrazol (PTZ).Methods:A kindling model of chronic epilepsy in rats was established by the injection of PTZ(37.5mg/d) intraperitoneally. The changes of behaviors and EEG of epileptic rats treated with VOL 500mg/kg、1000mg/kg, 1500mg/kg respectively were examined.Results:Three weeks later, the latencies of epileptic discharges in 3 groups of rats treated with VOL were 7.36±2.18min, 9.42±2.05 min, 11.19±1.95 min respectively and significantly prolonged as compared with that of PTZ group ,meanwhile both the frequency of epileptiform discharges and the degree of seizure decreased significantly( P <0.05).The effect of VOL was relevant to the size of VOL doses.Conclusions:VOL might have significant antiepileptic effects on PTZ-induced epilepsy in rats, with its effects occurring 3weeks later.
出处
《临床神经电生理学杂志》
2005年第2期95-98,共4页
Journal of Clinical Electroneurophysiology
