摘要
目的 :了解HBV感染者血清中PreS1与HBV -DNA之间的关系 ,以及对乙型肝炎诊断的价值。方法 :应用ELISA方法对 3 2 0例HBsAg阳性血清进行PreS1、HBVM检测 ,并与HBV DNA荧光定量PCR检测结果比较分析。结果 :HBeAg阳性组中 ,PreS1、HBV -DNA阳性率分别为 74 . 6%和 83 7%;HBeAg阴性组中PreS1、HBV DNA阳性率分别为 2 7 . 7%和 2 4 . 7%,PreS1、HBV DNA阳性结果比较 ,无显著性差异 (P >0 . 0 5 ) ,经相关回归分析 ,r =0 . 9911,y =-11 . 95 2 2 +1 . 2 661x。结论 :PreS1、HBV -DNA阳性检出率呈正相关 ,PreS1可作为HBV感染转归的重要指标。
Objectives:To learn the relationship between Pre-S1 antigen and HBV-DNA in the serum of cases infected with HBV and its diagnostic value to hepatitis B. Methods:We detected Pre-S1 and HBVM in the serum of 320 cases whose HBsAg was positive with ELISA and compared with the results detected with HBV-DNA fluorescence quantity PCR. Results: For the group that HBeAg was positive, and the positive rates of PreS1 and HBV-DNA were 74.6% and 83.7% respectively. For the group that HBeAg was negative, the positive rates of PreS1 and HBV-DNA were 27.7% and 24.7% respectively. There was not significant difference for the positive results between PreS1 and HBV-DNA (P>0.05). Through the correlation analysis, r = 0.9911 and y= -11.9522+1.2661x. Conclusions:There is positive correlation for the positive detection rates between PreS1 and HBV-DNA and PreS1 is an important indicator of prognosis of HBV infection.
出处
《四川省卫生管理干部学院学报》
2005年第1期1-2,共2页
Journal of Sichuan Continuing Education College of Medical Sciences
