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肝富集的转录因子与细胞色素P450基因的表达调控 被引量：1

Regulation of cytochrome P450 genes by liver-enriched transcription factors
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摘要 Cytochrome P450 (CYP) is a complex gene superfamily of proteins that metabolizes a myriad of endogenous and exogenous substrates. Liver-enriched transcription factors (LETF) play a role in the constitutive and tissue-specific expression of hepatic genes. In this review, six families of LETF that play a role in the tissue-specific, developmental, sexual and temporal regulation of CYP are discussed. Cytochrome P450 (CYP) is a complex gene superfamily of proteins that metabolizes a myriad of endogenous and exogenous substrates. Liver-enriched transcription factors (LETF) play a role in the constitutive and tissue-specific expression of hepatic genes. In this review, six families of LETF that play a role in the tissue-specific, developmental, sexual and temporal regulation of CYP are discussed.
作者 诸葛坚 余应年
机构地区 浙江大学医学院病理生理学教研室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2005年第5期1026-1029,共4页 Chinese Journal of Pathophysiology
基金 973项目(No.2002CB512901) 国家自然科学基金项目(No.39770868) 浙江省自然科学基金项目(No.397490)资助
关键词 细胞色素P450 肝富集的转录因子 肝细胞核因子 表达 Cytochrome P450 Liver-enriched transcription factors Hepatocyte nuclear factor Expression
分类号 R97 [医药卫生—药品]
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参考文献28

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  • 1兰雷,陈垦,王晖.炎症性肠病动物模型的研究概况[J].中国病理生理杂志,2004,20(7):1322-1325. 被引量：5
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中国病理生理杂志
2005年 第5期

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