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比较氰钴胺和弥可保降低2型糖尿病小鼠同型半胱氨酸的作用 被引量：5

Comparison of reducing the homocysteine level in type 2 diabetic mice between cyanocobalamin and (methylcobalamin) treatment
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摘要 2型糖尿病Kkay小鼠,以蛋氨酸喂养制备高胱氨酸血症模型。弥可保治疗两周同型血半胱氨酸水平明显低于氰钴胺治疗(2.2±0.2 vs 3.2±0.6μmol/L,P<0.05) In T2DM Kkay mice with hyperhomocysteinemia (HHcy)modeled by methionine feeding, the methylcobalamin-treatment group had lower Hcy level (μmol/L,±s) at the 2-nd week than that of cyanocobalamin treatment (2.2±0.2 vs 3.2±0.6,P<0.05 respectively).
作者 杨国庆 陆菊明 马芳龄 潘长玉
机构地区 解放军总医院内分泌科
出处 《中华糖尿病杂志（1006-6187）》 CSCD 北大核心 2005年第2期142-143,共2页
关键词 比较氰钴胺 弥可保 2型糖尿病 小鼠 同型半胱氨酸 脑血管疾病 Diatetes mellitus, type2 Hyperhomocysteinemia Vitamin B_(12)
分类号 R587.2 [医药卫生—内分泌]
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参考文献6

  • 1杨国庆,陆菊明,潘长玉.血浆同型半胱氨酸浓度与2型糖尿病视网膜病变的关系[J].中华内科杂志,2002,41(1):34-38. 被引量：62
  • 2Montalescot G, Ankri A, Chadefaux-Vekemans B, et al. Plasmsa homocysteine and the extent of atherosclerosis in patients with coronary disease. International. J Cardiol,1997,60:295-300. 被引量：1
  • 3Jacobsen DW,Gatautis VJ,Green R,et al. Rapid HPLC determination of total homocysteine and plasma :sex difference and correlation with cobalamin and folate concentrations in heathy subjects.Clin Chem,1994,40:873-881. 被引量：1
  • 4Fonseca VA,Mudaliar S,Schmidt B,et al. Plasma homocysteine concentration are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects. Metabolism,1998,47:685-689. 被引量：1
  • 5Ubbink JB, Vermaak WJ, van der Merwe A, et al. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr,1994 ,124:1927-1933. 被引量：1
  • 6Ubbink JB. Vitamin status and hyperhomocysteinemia in a healthy population. In: Graham I, Refsum H, Rosenburg I, eds. Homocysteine Metabolism: From Basic Science to Clinical Medicine. Boston:Kluwer Academic Publishers,1998.93-98. 被引量：1

二级参考文献10

  • 1Fonseca VA, Mudaliar S, Schmidt B ,et al. Plasma homocysteine concentration are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects. Metabolism, 1998,47:686-689. 被引量：1
  • 2Wollesen F, Brattstrom L, Refsum H, et al. Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. Kidney Int, 1999, 55:1028-1035. 被引量：1
  • 3Vaccaro O, Ingrosso D, Rivellese A, et al. Moderate hyper-homocysteinaemia and retinopathy in insulin-dependent diabetes. Lancet,1997,349:1102-1103. 被引量：1
  • 4Tsai JC, Wang H, Perrella MA, et al. Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest, 1996,97:146-152. 被引量：1
  • 50 Blom HJ, Kleinveld HA, Boers GH, et al. Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinaemia. Eur J Clin Invest, 1995,25:149-154. 被引量：1
  • 6Montalescot G,Ankri A,Chadefaux-Vekemans B,et al. Plasmsa homocysteine and the extent of atherosclerosis in patients with coronary disease. Int J Cardiol, 1997,60:295-300. 被引量：1
  • 7Gilfix BM, Blank DW, Rosenblatt DS. Novel reductant for deter-mination of total plasma homocysteine. Clin Chem, 1997,43:687-688. 被引量：1
  • 8Hoogeveen EK, Kostense PJ, Beks PJ, et al. Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study. Arherioscler Thromb Vasc Biol, 1998,18:133-138. 被引量：1
  • 9van den Berg M, Stehouwer CD, Bierdrager E, et al. Plasma homocysteine and severity of atherosclerosis in young patients with lower-limb atherosclerotic disease. Arherioscler Thromb Vasc Biol, 1996,16:165-171. 被引量：1
  • 10Drzewoski J, Czupryniak L, Chwatko G, et al. Total plasma homocysteine and insulin levels in type 2 diabetic patients with secondary failure to oral agents. Diabetes Care, 1999,22:2097-2099. 被引量：1

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二级引证文献10

中华糖尿病杂志（1006-6187）
2005年 第2期

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