摘要
目的 探讨IFN -α对慢性乙型肝炎患者CD1α树突状细胞的体内诱导作用。方法 在干扰素- α(IFN -α)抗乙型肝炎病毒的同时,采用流式细胞检测技术,检测21例慢性乙型肝炎患者外周血CD1α树突状细胞状况,观察IFN- α治疗前后慢性乙型肝炎患者CD1α树突状细胞的变化,同时观察对照组(15例)慢性乙型肝炎患者CD1α树突状细胞的变化。结果 IFN -α治疗组在IFN -α治疗3个月后CD1α树突状细胞占外周血单个核细胞的比率增加,对照组慢性乙型肝炎患者CD1α树突状细胞差异无显著性。抗病毒治疗组中,治疗后HBV DNA转阴组CD1α树突状细胞占外周血单个核细胞的比率高于未转阴组。结论 IFN -α在体内有诱导外周血单个核细胞产生树突状细胞的作用,IFN -α对慢性乙型肝炎患者CD1α树突状细胞的体内诱导作用可能是IFN -α抗乙型肝炎病毒的一重要免疫机制。
Objective The effects of IFN-α on peripheral circulating dendritic cells in patients with chronic hepatitis B were investigated.Methods CD1α dendritic cells were monitored in 21 cases with chronic hepatitis B who were treated with IFN-a and in 15 cases were not treated with IFN-α within three months (control group) by flow cytometry technique.Results In the group of IFN-α treatment,the percentage of CD1α dendritic cells in peripheral blood mononuclear cells was increased after three months of therapy.The increase of dendritic cells was more prominent in patients whose HBV-DNA became negative after IFN-α treatment.In control group,these changes were not observed.Conclusions CD1α dendritic cells might be induced by IFN-α in vivo.This might be an important immune mechanism of IFN-α treatment for chronic hepatitis B.
出处
《临床内科杂志》
CAS
2005年第5期325-326,共2页
Journal of Clinical Internal Medicine
基金
上海市卫生局青年科研基金项目(024Y12)
