摘要
目的:国内首例长期生存的活体小肠移植获得成功,而活体小肠移植术后的肠吸收功能、患者营养状况及饮食管理需要做长期、动态、连续的观察分析和评价。方法:从1999-05-20/2004-05-20对国内首例活体小肠移植术后患者饮食实行科学化管理、通过对消化道症状及营养指标的观察,移植肠吸收功能的监测、免疫抑制剂FK506全血质量浓度测定,全面观察移植肠的吸收功能的恢复。结果:至今患者健康生存5年余,自由进食,并参加工作,排成形便,每日一两次,体质量维持在56～58kg,血色素在120g/L以上,血清总蛋白、白蛋白正常。D-木糖吸收试验,尿中排出率在28%,FK506血药浓度维持在5.0～6.0ng/L,吸收功能稳定。全消化道钡餐检查,肠蠕动良好,无狭窄性改变。结论:活体部分小肠移植是治疗短肠综合征的一种理想方法。移植肠功能恢复可使患者获得良好的生活质量。
AIM:To observe,analyze and assess the intestinal absorption function,patients' nutritional status and the controlling of diet after living related small bowe l transplantation dynamicly and consecutively for a long term,based on the succe ss of first living related small bowel transplantation with a long term surviv al in China. METHODS:The first patient treated with living related small bowel transplanta tion successfully was controlled in diet scientifically,and the recovery of the transplanted intestinal absorption function was generally observed by observing alimentary tract symptoms and nutrition indexes,monitoring the transplanted inte stinal absorption function and assessing the whole blood mass and concentration of immunosuppressive agent FK506 from May 20, 1999 to May 20,2004. RESULTS:The patient had been living better for over 5 years after living rela ted small bowel transplantation,and had a free diet,enabled to work.He had an un obstructed defecation once or twice per day.His body mass ranged from 56 to 58 k g,hemochrome was above 120 g/L,and serum total protein,albumin was normal.After absorption test of D xylopyranose,his urinary outputting rate was 28%,the conc entration of FK506 maintained during 5.0 and 6.0 ng/L,and the absorption functio n was in a stable state.From the barium meal examination of the whole alimentary tract,vermiculation was good and no constricted changes were found. CONCLUSION:It is a good way to perform the living related small bowel transpl antation for the patients with short bowel syndrome.The patients get a good qual ity of life attributing to the regain of transplanted intestinal function.
出处
《中国临床康复》
CSCD
北大核心
2005年第14期50-52,共3页
Chinese Journal of Clinical Rehabilitation
