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急性冠脉综合征患者血清IL-18水平的检测及其意义 被引量:5

Detection and significance of serum IL-18 in patients with acute coronary syndromes
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摘要 目的检测急性冠脉综合征(ACS)患者血清白细胞介素18(IL18)的水平,并探讨其与血清高敏C反应蛋白(hsCRP)及血清肌钙蛋白I(cTnI)的关系。方法用ELISA法检测ACS患者74例,稳定型心绞痛(SAP)患者31例,及冠状动脉造影正常者22例(对照组l)血清IL18,同时免疫比浊法检测各组患者hsCRP,微粒子捕捉法检测cTnI。结果①ACS患者血清IL18、hsCRP与SAP组及对照组比较,均存在显著差异(P<0.01)。②急性心肌梗死(AMI)患者血清hsCRP较UAP患者显著升高(P<0.01),而IL18在两组比较无显著差异(P>0.05)。③ACS患者hsCRP与IL18显著正相关。④AMI患者cTnI与IL18无显著相关。结论IL18与急性冠脉综合征的发病密切相关,可作为急性冠脉综合征的一个新的重要的血清标志物。血清IL18及hsCRP正相关,提示多种炎症因子共同参与或相互作用参与了动脉粥样硬化的形成及急性冠脉综合征的发病过程。 AIM: To measure the serum concentration of interleukin-18(IL-18)in patients with acute coronary syndromes and investigate its relation with high sensitive C-reactive protein(hs-CRP)and cardiac troponin(cTnI). METHODS:The serum concentrations of IL-18,hs-CRP and cTnI were measured in 31 patients with stable angina pectoris(SAP),74 patients with acute coronary syndromes (ACS) and 22 controls(control)undergoing coronary angiography (CAG) by enzyme-linked immunosorbent assay(ELISA)or immunonephelometric assay or microparticle capture enzyme immunoassay. RESULTS: ①The serum levels of IL-18 and hs-CRP were significantly increased in ACS in comparison with SAP and control (P<0.01);②No difference in IL-18 was found between patients with unstable angina pectoris(UAP) and those with acute myocardial infarction(AMI)(P>0.05),but the serum concentration of hs-CRP was higher in patients with AMI than those with UAP (P< 0.05); ③The serum concentration of IL-18 was correlated with hs-CRP in ACS; ④Not similar to hs-CRP,the serum concentration of IL-18 was not correlated with cTnI in patients with AMI. CONCLUSION: Serum IL-18 concentration was significantly increased in patients with ACS and it can be a new and important serum marker in ACS.
出处 《心脏杂志》 CAS 2005年第2期142-144,共3页 Chinese Heart Journal
关键词 冠状动脉疾病 白细胞介素-18 高敏C反应蛋白 心肌肌钙蛋白 coronary disease interleukin-18 high sensitive C-reactive protein troponin
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