摘要
采用四条血管阻断方法制成家兔急性全脑缺血再灌流模型，观察家兔脑组织胞浆内ＳＯＤ及Ｎａ＋，Ｋ＋，Ｃａ（２＋），Ｍｇ（２＋）含量变化，结果发现家兔脑组织单纯缺血时ＳＯＤ活力明显下降（与正常对照组相比Ｐ＜０．０１），缺血再灌流后ＳＯＤ活力又较单纯缺血组进一步下降（Ｐ＜０．０１），Ｎａ＋，Ｃａ（２＋）在单纯缺血时含量增高（与正常对照组相比Ｐ＜０．０１），而Ｋ＋，Ｍｇ（２＋）则减少（Ｐ＜０．０１）；缺血再灌流后Ｎａ，Ｃａ（２＋）含量较单纯缺血组进一步增高（Ｐ＜０．０１），Ｋ＋，Ｍｇ（２＋）减少（Ｐ＜０．０１）．应用ＡＴＰ－氯化镁治疗后，上述指标与正常对照组相比无显著差异。
The model of forebrain ischeinia and reperfusion in rabbits was made by four vessls occlusion. The amounts of superoxide dimutase(SOD)and Na+,K+, Ca(2+),Ma(2+)ions in the cytosol of brain tissue were measured, The levels of SOD were decreased during the simple ischemia and the SOD activities were further reduced after reperfusion. The Na+, Ca(2+) ions were increased and K+, Mg(2+) ions were decreased during the simple ischemia, but the Na+,Ca ions were decreased during the simple ischemia, but the Na+,Ca(2+) ions were further increased and K+, Mg(2+) ions were further decreased after reperfusion. The above metioned changes in the ATP-magnesium chloride administation group were no different from normal control group.
出处
《延边医学院学报》
1994年第3期183-186,共4页
Journal of Medical Science Yanbian University
关键词
脑缺血
腺苷三磷酸
超氧化物歧化酶
cerebral ischemia
adenosine triphosphate
superoxide dismutase
