摘要
目的 调查不同省区军人精神分裂症患者5-HT2A受体基因T102C基因型频率在地理上的分布。方法 采用聚合酶 链反应的方法对不同省区的177例男性军人精神分裂症患者5-HT2A受体基因T102C多态进行基因型分析。结果 177例军人精 神分裂症患者5-HT2A受体基因T102C基因型频率分布分别为:A1A1为0.07～0.33,χ2=4.44,P=0.6171;A1A2为0.50～0.72,χ2 =1.14,P=0.9422;A2A2为0.17～0.29,χ2=0.93,P=0.9857;基因型频率与地区间差异均无显著相关性。结论 中国不同省区军 人精神分裂症患者5-HT2A受体基因T102C基因型频率在地理分布上比较均一。
Objective To investigate the geographic distribution of 5-HT2A T102C genotypes frequency in the PLA schizophrenia patients. Methods The 5-HT2A receptor gene T102C polymorphism was analyzed for genotyping by the method of polymerase chain reaction(PCR)in 177 male PLA schizophrenia patients. Results The distribution of 5-HT2A genotypic frequencies in 177 male PLA schizophrenia patients were 0.07~0.33(χ 2=4.44,P=0.617 1) for A1A1, 0.50~0.72 for A1A2 (χ 2=1.14, P=0.942 2), and 0.17~0.29 for A2A2 (χ 2=0.93, P=0.985 7), respectively. There was no significant correlation between 5-HT2A frequencies and different populations. Conclusion The frequencies of 5-HT2A T102C genotypes in the PLA schizophrenia patients were uniform in different populations.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2005年第3期266-267,共2页
Medical Journal of Chinese People's Liberation Army
基金
全军医药卫生"九五"基金资助课题(编号98D023)
