摘要
目的 深入研究中药当归Angelicasinensis的化学成分。方法 用硅胶柱色谱法和光谱分析法分离和鉴定化学成分。结果 除 3个已知的苯酞类结构外,从当归中又分离到 1个新的二聚苯酞衍生物和一对几何异构体,经光谱分析鉴定其结构分别为Z 3′, 8′, 3′a, 7′a 四氢 6, 3′, 7, 7′a 二聚藁本内酯 8′ 酮(1)、Z,Z′ 6, 6′, 7, 3′a 二聚藁本内酯(2)和 2的 8位几何异构体(3)。结论 化合物 1为新的二聚苯酞类衍生物,3为首次从当归中鉴定的二聚苯酞类衍生物。
Aim To study the chemical constituents of the roots of Angelica sinensis. Methods Silica gel column chromatography was used to separate the chemical constituents. Their structures were elucidated by chemical and spectral analysis (IR, MS, 1D and 2D NMR, etc.). Results Besides three known phthalide derivatives, one new dimeric phthalide derivative and a pair of epimer were isolated and their structures were identified as Z-3′,8′,3′a,7′a-tetrahydro-6,3′,7,7′a-diligustilide-8′-one (1), Z,Z′-6,6′,7,3′a-diligustilide (2) and the 8-epimer (3) of 2 on the basis of spectral data. Conclusion Compound 1 is a new dimeric phthalide derivative, and compound 3 was first reported from radix Angelica sinensis.
出处
《药学学报》
CAS
CSCD
北大核心
2005年第2期141-144,共4页
Acta Pharmaceutica Sinica
基金
国家中医药管理局中医药科学技术研究专项资助项目(02 03ZP09).
关键词
当归
Z-3′
8′
3′a
7′a-四氢-6
3′
7
7′a-二聚藁本内酯-8′-酮
E
Z′-6
6′
7
3′a-二聚藁本内酯
Angelica sinensis
Z-3′,8′,3′a,7′a-tetrahydro-6,3′,7,7′a-diligustilide-8′-one
E,Z′-6,6′,7,3′a-diligustilide
