摘要
用黏度法系统地研究了新型钌(Ⅱ)多吡啶配合物与DNA的相互作用.结果显示:在一定程度上增大配体的刚性平面,将增大钌(Ⅱ)多吡啶配合物插入DNA碱基对的能力,但当配体的刚性平面太大时,却又由于位阻作用而阻碍了配体对DNA的插入;能够使配体平面性增强的分子内氢键的形成,有利于配合物对DNA的插入作用;配体中引入较大体积的取代基而引起的配体芳环间的扭转,将导致钌(Ⅱ)多吡啶配合物只能“部分地”或“非经典地”插入DNA.
The binding of polypyridyl Ru(Ⅱ) complexes to DNA was investigated using viscosity measurement. In general, the extension of ligand planarity might increase the ability of insertion of the complexes to DNA base pairs, but too big ligands would hinder the insertion. The formation of intramolecular hydrogen bonding extends the ligand planarity and increases the insertion ability of the complex to DNA. It is concluded that the torsion among the aromatic rings of ligands, due to introduction of the bulky substituent groups, makes the complexes partially or non-classically insert into DNA.
出处
《化学研究》
CAS
2005年第1期5-8,共4页
Chemical Research
基金
南京大学配位化学国家重点实验室开放基金资助项目.
