摘要
为研究棉酚对子宫内膜异位症的治疗作用及其机理，２４只经自体子宫内膜移植引起的实验性子宫内膜异位症雌鼠随机分成对照组和棉酚治疗组。对照组予以０．５％Ｔｗｅｅｎ８０皮下注射，棉酚组予以０．５％Ｔｗｅｅｎ８０溶释的棉酚混悬液以５ｍｇ／（ｋｇ·ｄ）皮下注射２～３周。结果表明，与对照组比较，经２～３周棉酚治疗的实验性子宫内膜异位症雌鼠卵巢重量和血浆雌二醇明显降低（Ｐ＜０．０１）；而子宫重量和子宫内膜移植病灶也明显减少（Ｐ＜０．０５），棉酚引起移植子宫内膜异位病灶消退率为６６．６％，研究证实：棉酚可有效地阻遏实验性子宫内膜异位病灶的生长发育并可使其快速消退，其作用部位在卵巢和子宫水平而非在下丘脑－垂体水平，实验进一步证实棉酚对子宫内膜异位症的治疗作用并可望开发成为新一代治疗药物。
Since gossypol may have a beneficial effect in the treatment of endometriosis we have examined the effect of gossypol in a rat endometriosis model.Rats (n=24) with surgically induced endometriosis were divided into two treatment groups:vehicle control and gossypol. Each group was further subdivided into two treatment periods of either 2 or 3 weeks of injections. The vehicle (0.5% tween 80)and the dose of gossypol(5.0 mg/kg·day) for this experiment was chosen as a result of our previous studies that were designed to determine the minimus effective dose of gossypol. After 2 or 3 weeks of treatment the weight of the ovary and systemic estradiol concentrations were significantly reduced in the gossypol treated rats versus vehicle control rats(P<0.01).This reduced ovarian activity wasassociated with a decrease in the weight of the uterus and the size of the endometriotic implants (P<0.05). These studies reiterated the suppressive effect of gossypol upon the reproductive system and suggested that gossypol may have a therapeutic benefit in the treatment of endometriosis.
出处
《现代妇产科进展》
CSCD
1994年第1期15-18,共4页
Progress in Obstetrics and Gynecology
