摘要
4-苯基-1-丁醇是一种重要的药物中间体。文章以苯和丁二酸酐为起始原料,经付克酰基化得3-羰基苯丁酸;通过对羰基还原成亚甲基的方法进行研究,确定了通过Wollf-Kishner还原法合成苯丁酸,然后通过酯化和硼氢化钠还原酯等反应合成了4-苯基-1-丁醇,使总收率不低于35%。该合成方法避免了毒性较大的锌-汞齐,革除了价格昂贵的氢化铝锂,使之更适合于工业化生产。
phenyl-1-butanol is an important intermediate product. It was prepared by Friedel-crafts acylation and reduction with benzene and succinic anhydride. The yield is over 35%. The synthesis route avoided the poisonous reagent,Zn-Hg/HCl,and got rid of expensive LiAlH4. The new synthesis route is more suitable for commercial process.
出处
《广州化学》
CAS
2005年第1期31-34,共4页
Guangzhou Chemistry
关键词
苯
丁二酸酐
4-苯基-1-丁醇
反应
合成
benzene,succinic anhydride,4-phenyl-1-butanol,reaction,synthesis
