摘要
用鼠伤寒沙门氏菌／微粒体试验方法研究了两种茶叶对Ｎ－亚硝胺合成的阻断作用。在模拟人胃液的条件下，亚硝酸钠与二甲基胺发生亚硝化反应生成Ｎ－亚硝胺。亚硝胺在Ａｍｅｓ平板掺入法中能引起鼠伤寒沙门氏菌ＴＡ９８，ＴＡ１００的致突变作用。当加入１％、５％和１０％剂量的茶叶浸出液后，可阻断Ｎ－亚硝胺的合成，抑制突变率呈剂量－反应关系。
Blocking action of two kinds of teas on formation of nitrosamines in vitro were studied by Salmonella typhimurium/microsome assay. Nitrosamines were formed through reaction between sodium nitrite and dimethylamine in the imitating condition of human gastric juice. Nitrosamines could induce the mutation effect in Salmonella typhimurium TA98 and TA100 by Ames test. The formation of N-nitrosamine could be blocked, when 1%, 5% and 10% tea water extracts were added, inhibiting rates of mutation showed dose-reaction relationships.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1994年第6期541-544,共4页
Academic Journal of Second Military Medical University
关键词
茶
亚硝胺
抑制突变
体外
tea
nitrosamines
inhibitory mutagenesis
in vitro
