摘要
微量注射大豆皂甙（ＴＳ）到下丘脑后核（ＰＨＮ）能引起平均动脉压（ＭＡＰ）升高，心率加快，其效应与向ＰＨＮ内注入ＮＰＹ相似。分别注入不能引起血压、心率发生明显变化的微量ＴＳ、ＮＰＹ，如果合发注入ＰＨＮ则可引起血压、心率的显著变化，表明二者有加强作用。Ａｔｒｏｐｉｎｅ可以对抗ＴＳ、ＮＰＹ或ＴＳ＋ＮＰＹ同时注入ＰＨＮ的升压效应，提示ＮＰＹ是通过激活脑内Ｍ受体实现升压效应，而ＴＳ的心血管效应又可能是经过脑内ＮＰＹ介导和加强的。
MAP was increased and the heart rate was accelerated after micrcinjection of TSinto
PHN。 The cardiovascular effect of TS was similar to the effect of NPY in PHN, Separate
mi-croinjection of NPY or soyasaponin could not cause significant cardiovascular respoi1se,
but com-bined injection of them togother wotild result in a prominent、pressor effect,indicating
that a rein-forcing effcet exists between these two pressor action。 This synergic pressor
action was attenuat-ed by atropine prior injection of them into the CNS, no matter when
soyasapoin and NPY wereinjeeted seprately or simultaniously。 These findings suggested
that the effect of NPY is realizedby M receptor activated in PHN, and the cardiovascular effects
of TS is, however ,mediated byNPY.
出处
《白求恩医科大学学报》
CSCD
1994年第5期444-445,共2页
Journal of Norman Bethune University of Medical Science
关键词
神经肽Y
生理学
大豆
皂甙
M受体
neuropeptide Y/PH
soyasaponin receptor
mtiscarinic/PH
