摘要
采取因职业而接触乙烯类或苯类诱变剂的孕妇静脉血和其新生儿脐带血进行SCE和MN测定,发现接触两类诱变剂的母血SCE分别为8.55±0.84和9.44±1.12,均高于对照组母血SCE(7.68±1.40);而微核率分别为0.833‰和0.75‰也高于对照组母血微核率(0.267‰);接触两类诱变剂的脐血SCE分别为8.44±1.43和8.75±0.88,均高于对照组脐血SCE(6.71±1.27);而微核率分别为0.727‰和0.818‰,也分别高于对照组脐血微核率。结果还表明母亲被动吸烟增强了化学诱变剂对新生儿的遗传毒性作用。本研究首次发现乙烯类诱变剂对新生儿具有遗传危害。
Assay for sister chromatid exchange (SCE) and micronucleus (MN) was performed on blood lymphocytes of pregnant women, occupationally exposed to vinyl compounds and benzene derivatives, and umbilical cord blood of their newborns. The frequences of SCE in exposed mothers (8.55±0.84, 9.44±1.12) and their newborns (8.44±1.43, 8.75±0.88)were higher than that of the controls (7.68±1.40, 6.71±1.27). The MN rates showed increment in the exposed mothers (0.833‰, 0.75‰) and their babies (0.727‰,0.818‰)as compared with that of the controls (0.267‰). The results also showed that the pregnant women smoking involuntary enhance genetoxic effects of some mutagens to their newborns. This study initially showed that the vinyl compounds could bring about effect on newborns.
出处
《内蒙古医学院学报》
1993年第2期83-86,共4页
Acta Academiae Medicinae Neimongol
关键词
姊妹染色
单体交换
微核
诱变剂
乙烯类化合物
sister chromatid exchange
micronucleus
mutagens
vinyl compounds
benzene derivatives
