摘要
目的:建立可控的痹得治片含量测定标准。方法:采用正相高效液相法测定痹得治片中士的宁的含量,以硅胶为填料,正己烷—二氯甲烷—无水甲醇—三乙胺(47.5:47.5:5:0.1)为流动相,检测波长254nm。结果:该方法能理想地分离痹得治片中士的宁,士的宁平均回收率为98.70％,精密度(RSD)为0.75％(n=5)。结论:所建立的含量测定标准可行、可控,测定结果准确,能有效地反映痹得治片的内在质量。
Objective: To establish an accurate and effective method for assay in qualification standard of Bidezhi Tablets. Method: Used OP-HPLC method to determine the content of strychnine in Bidezhi Tablets., selected a column of silica gel, n—hexane—dichloro methane—dehydrated methanol—triethylamine (47.5: 47.5: 5: 0.1)as the mobile phase, and the detection wavelength was 254nm. Result: This method can seperate strychnine perfectly, the average recovery of strychnine was 101.6% and RSD was 2.6%(n=5). Conclusion. This method for assay in qualification standard of bidezhi tablets is reliable and accurate.
出处
《中国药品标准》
CAS
2000年第3期33-34,3,共3页
Drug Standards of China
