摘要
乙基纤维素是广泛的水不溶性纤维素衍生物,可制成缓释药丸及具有缓、控释要求的新剂型的辅料.本文研究了基于超临界反溶剂(SAS)过程的乙基纤维素微粒制备原理及其实现方法,以乙醇为有机溶剂、超临界CO2为反溶剂制备出了平均直径在20-40nm范围内的乙基纤维素超细微粒.通过傅立叶红外光谱分析了乙基纤维素超细微粒的结构,从特征基判断其结构没有发生变化.
Supercritical anti-solvent (SAS) process is a recently developed technology to produce micro-particles and nano-particles. In this paper, a continuous apparatus to conduct experiments of SAS process is presented. By use of this apparatus the effects of pressure, temperature, solution concentration and nozzle diameter on the shape, size and distribution of the particles were investigated for the Ethyl-cellulose ethanol - CO2 system. The experimental results showed that Ethyl-cellulose micro-particles with diameters ranging from 20 nm to 40 nm could be obtained by SAS process when ethanol was used as an organic solvent.
出处
《大连大学学报》
2004年第6期22-25,共4页
Journal of Dalian University
基金
国家自然科学基金资助项目(20176003)
