摘要
目的 观察幽门螺杆菌 (Hp)感染与脑梗死复发的关系。方法 用酶联免疫吸附分析 (ELLESA)法对 51 2例初发脑梗死病例的血清标本行Hp -IgG定性检查 ,确定Hp感染。其中Hp阳性 365例 ,随机分为观察组 (A组 ) 1 81例和Hp阳性对照组 (B组 ) 1 84例 ,Hp阴性 1 4 7例作为阴性对照组 (C组 )。A、B、C三组均给予脑梗死的一般治疗 ,A组除给予一般治疗外 ,在发病后一个月内还给予抗Hp治疗。观察三组 ,二年内的累计复发率。结果 A、B、C三组的失访率分别为 1 % (2 / 1 81 )、2 % (3/ 1 84)、1 % (2 / 1 4 7) ,复发率分别为1 2 % (2 1 / 1 79)、33 % (59/ 1 81 )、1 1 % (1 6/ 1 4 5)。A组与B组比较复发率的差异有统计学意义 (P <0 .0 1 ) ,B组与C组比较复发率的差异有统计学意义 (P <0 .0 1 ) ,A组与C组比较复发率的差异无统计学意义 (P >0 .0 5)。结论 Hp阳性的脑梗死患者较Hp阴性者复发率高 。
Objective To observe the relation of Helicohacter Pylori infection and recuring with brain infarct. Methods Serum samples of 512 first brain infarct cases competent Hp-IgG confirm to check Hp infect with enzyme linked immuncsorben assay(ELLESA).The Hp positive 365 was divided to observe group (A group) 181 and contrast the group (B group) 184 Hp at random. Negative 147 of Hp,as contrasting the group (group C). Group A, group B and group C were given the generally treatment of brain infarct. Group A was performed generally treatment,and were given the resist Hp treat 7 days in one months after having illness coming on. Followed up a case by regular visits to once until the end two years in one year after having illness coming on, Observe the recuring rate of accumulative total in two years of three groups. Results The lose visiting rate of group A,B and C respectively was 1% (2/181),2% (3/184),1%(2/147)mistake of group. The recuring rate respectively was 12% (21/179), 33%(59/181),11%(16/145).Relatively the difference of the recuring rate had statistics meanings in group A and group B(χ~2=22.67,P<0.01,RR=0.36,95%CI:0.58～1.96).Relatively the difference of the recuring rate had statistics meanings in group B and group C(χ~2=21.13,P<0.01,RR=2.95,95%CI:1.78～4.91).Relatively the difference of the recuring rate does not have statistics meaning in group A and group C(P=0.84). Conclusion The positive brain infarct patient of Hp is higher than the recuring rate of the negative one . The recurring of eliminating hindbrain infarct of Hp is reduced.
出处
《中国煤炭工业医学杂志》
2005年第2期128-129,共2页
Chinese Journal of Coal Industry Medicine
关键词
幽门螺杆菌
特异性抗体
脑梗死
复发
helicohacter pylori infection
helicohacter pylori infection peculiar antibody IgG
brain infarct
recurring
