摘要
目的 观察法莫替丁、呋喃唑酮、阿莫西林、果胶铋四联疗法治疗幽门螺杆菌阳性消化性溃疡的疗效和安全性。方法 将幽门螺杆菌阳性溃疡患者 90例随机分为二组 :观察组 44例 ,予以法莫替丁 2 0mg ,2次 /d、呋喃唑酮 1 0 0mg ,3次 /d、阿莫西林 1 0 0 0mg ,2次 /d、果胶铋 1 50mg ,3次 /d ,疗程 1周 ,治疗 1周后继续单独用法莫替丁 2 0mg ,2次 /d ,治疗 3周 ;对照组 46例 ,予以奥美拉唑 2 0mg、阿莫西林 1 0 0 0mg、甲硝唑 40 0mg ,2次 /d ,疗程 1周 ,治疗 1周后继续单独用奥美拉唑 2 0mg ,2次 /d ,治疗 3周。治疗后每周观察临床症状改善情况 ,用药结束 1个月后复查胃镜观察溃疡愈合情况并检测幽门螺杆菌。结果 观察组和对照组治疗 1周后的症状缓解率分别为 97.7%、97.8% ,观察组和对照组的溃疡愈合率分别为 90 .9%和 87.0 % ;观察组和对照组的幽门螺杆菌根除率分别为 88.6 %和87.0 % ,以上各项比较差异均无统计学意义 (P >0 .0 5)。结论 法莫替丁、呋喃唑酮、阿莫西林、果胶铋四联疗法能有效根除幽门螺杆菌、改善临床症状和促进溃疡愈合 。
Objective To observe the efficacy and safety of quadruple therapy with famotidine,furazolidone,amoxicillin and guojiaobi in the treatment of Helicobacter pylori positive peptic ulcer. Methods 90 patients with Helicobacter pycori positive peptic ulcers were randomly divided into two groups: 44 cases in treatment group, which were treated for 1 week with famotidine 20mg bid.,furazolidone 100mg tid.,amoxicillin 1000mg bid. and guojiaobi 150mg tid., 1 week later, continue treated with famotidine 20mg bid. for 3 weeks; 46 cases in control group, which were treated with omeprazole 20mg bid., amoxicillin 1000mg bid. and metronidazole 400mg bid., 1 week later, continue treated with omeprazole 20mg bid. for 3 weeks. Clinical symptoms were observed every week. One month after treatment, the eradication rate of Helicobacter pylori and the healing rate of peptic ulcer were evaluated according the results of repeated endoscopy. Results The relief rates of clinical symptoms in treatment group and control group were 97.7% and 97.8% respectively at one week finishing regimen (P>0.05),the ulcer healing rates in both groups were 90.9% and 87.0%(P>0.05). Conclusion The quadruple therapy is effiective and safe for eradicating Helicobacter pylori, relieving symptoms and curing peptic ulcer, and the treatment price is lower as well.$$$$
出处
《中国煤炭工业医学杂志》
2005年第2期117-118,共2页
Chinese Journal of Coal Industry Medicine
