摘要
目的观察雷尼替丁、呋喃唑酮、克拉霉素、果胶铋四联疗法治疗幽门螺杆菌阳性消化性溃疡的疗效和安全性。方法将幽门螺杆菌阳性溃疡患者100例随机分为两组:观察组50例,予以雷尼替丁300 mg、呋喃唑酮100 mg、克拉霉素250 mg、果胶铋300 mg,2次/d,疗程1周;对照组50例,予以奥美拉唑20 mg、克拉霉素250 mg、呋喃唑酮100mg,2次/d,疗程1周。治疗后每周观察临床症状改善情况,用药结束1个月后复查胃镜观察溃疡愈合情况并检测幽门螺杆菌。结果观察组和对照组治疗1周后的症状缓解率分别为94%、96%,观察组和对照组的溃疡愈合率分别为88%和90%;观察组和对照组的幽门螺杆菌根除率分别为92%和94%,以上各项比较差异均无统计学意义(P>0.05)。结论雷尼替丁、呋喃唑酮、克拉霉素、果胶铋四联疗法能有效根除幽门螺杆菌、改善临床症状和促进溃疡愈合,且价格低廉。
Objective To observe the efficacy and safety of quadruple therapy with ranitidine , furazolidone,clarithromycin and guojiaobi in the treatment of Helicobacter pylori positive peptic ulcer. Methods 100 patients with Helieobacter pyeori positive peptic ulcers were randomly divided into two groups ： 50 cases in treatment group , which were treated for 1 week with ranitidine 300mg bid. , furazolidone 100mg tid. clarithromycin 250mg bid. and guojiaobi 300mg bid; 50 cases in control group , which were treated for 1 week with omeprazole 20mg bid. clarithromycin 250mg bid. and furazofidone 100mg bid . One month after treatment , the eradication rate of Heficobacter pylori and the healing rate of peptic ulcer were evaluated according the results of repeated endoscopy. Results The relief rates of clinical symptoms in treatment group and control group were 94 % and 96 % respectively at one week finishing regimen（P〉0.05） , the ulcer healing rates in both groups were 88 % and 90% （P〉0.05）. Conclusion The quadruple therapy is effiective and safe for eradicating Helicobacter pylori , relieving symptoms and curing peptic ulcer , and the treatment price is lower as well.
出处
《临床和实验医学杂志》
2006年第10期1505-1506,共2页
Journal of Clinical and Experimental Medicine
