摘要
背景:针刺减肥的疗效已在临床得到证实。中枢神经系统在针刺减肥中所起的作用如何,中枢调节与外周作用之间的又有哪些内在联系呢?目的:研究针刺对肥胖者下丘脑摄食中枢的影响。设计:以实验动物为研究对象的随机对照研究。单位:一所中医药大学的临床医学院。材料:实验于1998-06/2000-01在南京中医药大学针灸重点实验室完成。选用50只SD雄性大鼠,随机分为针刺组,肥胖组,正常组。方法:高脂致肥饲料喂养SD大鼠、制作实验性肥胖模型。应用神经细胞微电极记录和脑立体定位技术,通过对实验性肥胖大鼠针刺治疗,观察下丘脑外侧区饥饿中枢、腹内侧核饱食中枢神经细胞单位时间内电活动(Hz)。主要观察指标:各组大鼠针刺前后同期体质量变化及各组大鼠下丘脑外侧区、腹内侧核放电频率。结果:针刺能够明显降低下丘脑外侧区的兴奋性,其中针刺组,肥胖组,正常组的值分别为(9.4±3.7),(21.4±6.8),(9.1±5.2)Hz(P<0.01),提高腹内侧核的电活动频率,3组分别为(21.1±4.3),(5.0±1.3),(14.5±2.2)Hz(P<0.01),抑制肥胖鼠亢进的食欲,减少热卡的摄入,达到减肥目的。结论:针刺对肥胖动物中枢神经核团的调整作用是针刺减肥的主要机制之一。
BACKGROUND:The therapeutic effects of acupuncture on weight loss have been verified.How does the central neural system act on weight loss with acupuncture?What relationships are there between the central regulation and peripheral action? OBJECTIVE:To study the effect of acupuncture on feeding center of hypothalamus in obese cases. DESIGN:Randomized and controlled study in which the experimental animals were taken as the subjects. SETTING:Clinical medical college of a university of traditional chinese medicine. MATERIALS:The experiment was performed in Key Laboratory of Acupuncture and Moxibustion in Nanjing University of Traditional Chinese Medicine from June 1998 to January 2000.Fifty SD male rats were employed and randomized into acupuncture group,obese group and normal group. METHODS:The experimental obese model was prepared by feeding SD rats with high-fat forage.Microelectrode record of nerve cell and cerebral stereotaxic technique were applied,by the treatment with acupuncture on experimental obese rats,the electric activity(Hz) of nerve cell was observed at unit time in hunger center of lateral hypothalamus area(LHA) and satiety center of ventral medium nucleus of hypothalamus(VMH). MAIN OUTCOME MEASURES:Mass changes at the same stage before and after acupuncture in rats of every group and discharge frequency in LHA and VMH in rats of every group. RESULTS:Acupuncture reduced remarkably the excitability in LHA,the values of which in acupuncture, obese and normal groups were(9.4±3.7),(21.4±6.8),(9.1±5.2)Hz respectively(P< 0.01);improved electric activity frequency in VMH,the values of which in 3 groups were(21.1±4.3),(5.0±1.3),(14.5±2.2)Hz,respectively(P< 0.01),inhibited excessive appetite of obese rats and reduced calorie intake so as to achieve weight loss. CONCLUSION:The regulation of acupuncture on central neural nuclei in obese animals is one of the important mechanisms on weight loss.
出处
《中国临床康复》
CSCD
北大核心
2005年第7期193-195,共3页
Chinese Journal of Clinical Rehabilitation
基金
国家自然科学基金资助项目(39970923)~~
