摘要
目的探讨运动训练对老年慢性心力衰竭患者血管内皮功能炎性标志物的影响,具体包括粒细胞吞噬细胞克隆刺激因子(GMCSF)、吞噬细胞吸附蛋白(MCP1)、可溶性细胞内吸附分子1(sICAM1)及可溶性血管吸附分子1(sVCAM1)等在治疗前、后的变化情况。方法共选取48例心功能稳定的慢性心力衰竭患者,将其随机分为2组训练组(n=24)及休息组(n=24),2组患者均给予内科常规治疗,训练组患者在此基础上同时进行运动训练;并分别在治疗前及治疗12周后对2组患者进行GMCSF、MCP1、sICAM1、sVCAM1及6min步行试验等检查。结果运动训练可以显著降低训练组患者外周炎性标志物的浓度(均P<0.05),增加6min步行距离(P<0.05);休息组患者治疗12周后与入院时比较,上述各指标间差异均无统计学意义(P>0.05)。结论运动训练可以显著减轻慢性心力衰竭患者的炎性反应,并改善其运动功能。
Objective To explore the effects of physical training on serum activity of some peripheral inflammatory markers associated with endothelial dysfunction, such as granulocyte macrophage-colony stimulating factor (GM-CSF), macrophage chemoattractant protein-1 (MCP-1), soluble intercellular adhesion molecule-1(sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in patients with chronic heart failure. Methods Forty-eight patients were enrolled and randomly divided into two groups: a training group and a rest group. The patients of both groups were both given conventional internal medicine therapy, and the patients of the training group were given physical training in addition. The serum levels of GM-CSF, MCP-1, sICAM-1 and sVCAM-1 in patients of the two groups were determined with stable chronic heart failure before and after 12 weeks of programmed physical training. At the same time, the motor functional status of chronic heart failure patients was evaluated by using the 6-minute walking test. Results It was shown that the physical training produced a significant reduction in serum GM-CSF, MCP-1, sICAM-1 and sVCAM-1 as well as a significant improvement in performance of the 6-minute walking test. Conclusion The physical training could significantly alleviate the inflammation reaction and improve the motor function of patients with chronic heart failure.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2005年第2期100-102,共3页
Chinese Journal of Physical Medicine and Rehabilitation
