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腹腔注射胰岛素或其B链肽对NOD小鼠胰岛TNF/TNFR1系统表达的影响 被引量:1

Expression of TNF/TNFR1 system in islets of NOD mice immunized by insulin or its B chain peptide
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摘要  以胰岛素或其B链肽 (9 23)免疫 4周龄NOD小鼠,可下调胰腺干扰素γ、肿瘤坏死因子(TNF) α、TNF受体 1 (TNFR1 )、CPP32mRNA表达,下调胰岛细胞及浸润的炎症细胞TNF α、TNFR1、CPP32蛋白表达,减轻胰岛炎程度,降低糖尿病发病率。 Four week old NOD mice were immunized by insulin or its B chain peptide (9 23). This procedure down regulated the expression of interferon γ, turmor necrosis factor (TNF) α, TNF receptor 1 (TNFR1) and CPP32 mRNA in pancreas, down regulated the expression of TNF α, TNFR1 and CPP32 proteins in islets and inflammatory cells, attenuated the degree of insulitis and decreased the diabetic incidence.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2005年第1期77-78,共2页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金资助项目(30070356 ) 山西省自然科学基金资助项目(20021103)
关键词 TNFR NOD小鼠 胰岛素 CPP32 腹腔注射 蛋白表达 TNF受体 胰岛细胞 mRNA表达 Diabetes mellitus, type 1 Insulin Apoptosis Immune tolerance
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参考文献9

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二级参考文献1

  • 1Zhang Z J,Proc Nat Acad Sci USA,1991年,88卷,10252页 被引量:1

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