摘要
目的 探讨我国艾滋病 (获得性免疫缺陷综合征 ,AIDS)患者幽门螺杆菌 (Helicobacterpylori,Hp)感染情况 ,以及与CD4计数的关系。方法 对有消化道症状的AIDS患者 6 2例、人类免疫缺陷病毒 (HIV)阴性患者 2 1例行胃镜检查 ,并对活检黏膜行快速尿素酶及病理检测明确有无Hp感染。根据CD4计数将AIDS患者分为两组 :A组 ,CD4计数大于 10 0 /μl(2 9例 ) ;B组 ,CD4计数小于 10 0 /μl(33例 )。 结果 AIDS组Hp检出率为19.4 % (12 /6 2例 ) ,其中 :A组 31.0 % (9/2 9例 ) ;B组 9.1% (3/33例 )。HIV阴性对照组为 5 2 .4 % (11/2 1例 )。AIDS组Hp检出率低于对照组 (P <0 .0 5 ) ;而B组Hp检出率显著低于对照组 (P <0 .0 0 1)。结论 AIDS患者Hp感染率低于HIV阴性患者 ,原因可能与CD4细胞计数低下有关。
Objective To evaluate the prevalence of Helicobacter pylori and relationship with the absolute CD4 counts. Methods Eighty-three patients (62 AIDS patients and 21 HIV-negative control group patients) with digestive symptoms were evaluated with upper endoscopy and antral gastric biopsy. Samples were studied with Warthin-Starry staining and rapid urease test to determine the status of Helicobacter pylori infection. The patients of AIDS were stratified based on CD4 counts: group A,HIV-positive with CD4 counts greater than 100/μL(29 cases); group B, HIV-positive with CD4 counts less than 100/μL(33 cases). Results The prevalence of Helicobacter pylori infection in AIDS patients was 19.4%(12/62 cases),in which the two groups were as follows: group A 31.0%(9/29 cases), group B 9.1%(3/33 cases); and control group was 52.4%(11/21 cases). The prevalence of Helicobacter pylori in AIDS patients was lower than that of control group(P< 0.05).The prevalence of Helicobacter pylori in AIDS patients with CD4 counts less than 100/μL was significantly lower than that of control group(P< 0.001). Conclusion Lower Helicobacter pylori infection in AIDS patients may be relevant with the absolute CD4 counts.
出处
《临床荟萃》
CAS
北大核心
2005年第4期181-183,共3页
Clinical Focus
