摘要
目的 对比研究腹腔镜胆囊切除术 (Laparoscopiccholecystectomy,LC)和开腹胆囊切除术 (Opencholecystectomy ,OC)围手术期对TH1/TH2细胞 (辅助性T细胞 )平衡的影响及其调控细胞因子分泌状态。方法 随机选择行LC和OC患者各 30例 ,所有患者于术前、术后 6、2 4、4 8h取外周静脉血测定TH1、TH2细胞含量及血浆TNFα、IL 10水平。结果 OC组术后TH1明显减少 ,炎性因子TNFα明显下降 ;而TH2明显增加 ,抗炎因子IL 10明显升高。TH1/TH2比值 ,TNFα/IL 10比值均降低。LC组术后各指标均无明显变化 ,与OC组有显著差异。结论 LC可明显降低术后TH1/TH2细胞的偏移程度 ,对术后免疫功能干扰小 ;LC可减少抗炎因子和炎性因子的变化程度 ,从而有利于患者术后恢复。
Objective To study comparatively the influences of laparoscopic cholecystectomy (LC) and open cholecystectomy(OC) on TH1/TH2 balance and TH1/TH2 cytokine secretion.Methods Immune function was examined in patients undergoing LC(n=30) and OC(n=30) for chronic cholecystitis and gallstones. T-helper cell content and TNFα and IL-10 levels were assessed before operation and 6,24,48 hours after operation.Results After operation,the levels of TH1 cell and TNFα,and the TH1/TH2 ratio and TNFα/IL-10 ratio decreased significantly,but TH2 and IL-10 increased significantly in OC group.The difference between LC and OC was significant.Conclusion LC has less influence on TH1/TH2 balance and immunologic suppression postoperatively,and on pro-inflammatory and anti-inflammatory balance,which is beneficial to the recovery of LC patients.
出处
《武警医学》
CAS
2005年第1期27-30,共4页
Medical Journal of the Chinese People's Armed Police Force
