摘要
【目的】观察复方黄芪胶囊长期毒性反应,为临床用药提供科学依据,保证用药安全。【方法】以高剂量组5g/kg ,中剂量组3g/kg ,低剂量组1g/kg给大鼠连续灌服12w、停药2w ,分别测量大鼠体重,测定血液学和血液生化学指标,并作组织病理学检查。【结果】复方黄芪胶囊各剂量组动物的观测指标与空白对照组比较,均无显著性差异。病理检查各脏器组织均未见药物中毒性病理形态学改变。停药后也未见药物延迟性毒性反应。【结论】复方黄芪胶囊长期用药对大鼠无明显毒性,推论临床拟用剂量是安全的。
To observe the chronic toxicity in experimental animals treated with Fufanghuangqi Capsula,to provide the scientific basis for its clinical usage and to ensure it is used safely.The chronic toxicity experiments were performed on high dosage group 5 g/kg,middle dosage group 3 g/kg and low dosage group 1 g/kg,one daily for 12 weeks,for 2 weeks of stopping adiministration The rat weights,the indexes of hemotology and biochemistry were determined,and the pathological examination were carried out.The indexes have no significant difference by comparing with control group,the pathological examination was not discovered significant pathological changes with relation of drug toxicity and the delayed toxicity reaction in stopping adiministration later.[Conclusion]The Fufanghuangqi Capsula has no significant toxicity for long-term adiministration in rats, and infers that the drawing up doses in clinic will be safe.
出处
《武警医学院学报》
CAS
2005年第2期108-110,共3页
Acta Academiae Medicinae CPAPF
关键词
复方黄芪胶囊
毒性试验
Fufanghuangqi Cansula
Toxicity test
