摘要
硝基苯经溴代、还原、重氮化后水解得到间溴苯酚,再在无溶剂条件下用硫酸二甲酯甲基化得到间溴苯甲醚,总收率37%。
m-Bromoanisole was synthesized from nitrobenzene by bromination, reduction, diazotization and hydrolysis to give m-bromophenol followed by solvent-free methylation with an overall yield of 37%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第2期73-74,共2页
Chinese Journal of Pharmaceuticals
关键词
间溴苯酚
间溴苯甲醚
曲马多
中间体
合成
m-bromophenol
m-bromoanisole
tramadol
intermediate
synthesis
