摘要
目的评价中药脑疏宁对创伤性脑损伤 (TBI)后神经功能的保护作用。方法按Feeney自由落体撞击法造成TBI模型 ,通过木条行走实验评价伤后大鼠的神经功能恢复情况 ,并在伤后不同时间点观察脑组织含水量及病理改变。结果伤后 1周内大鼠完成木条行走作业的能力明显受损。经脑疏宁治疗后 ,TBI大鼠神经功能明显改善 ,脑组织含水量及病理改变减轻。结论中药脑疏宁可以促进颅脑损伤后神经功能的恢复 ,可能与早期减轻脑水肿、保护脑组织有关。
ObjectiveTo observe the protective effects of Chinese medicine Naoshuning on neurological deficits following traumatic brain injury (TBI) in rats.MethodsCerebral contusion was produced by dropping weight,the beam walking task was employed to observe neurological functional changes,water content in the brain tissue and neuropathological changes were also evaluated.ResultsWithin one week the ability to process in beam walking task was significantly lessened,the outcome of beam walking task of Naoshuning group was significantly better than that of the model group. Water content in the brain tissue and neuropathological changes were also alleviated in Naoshuning group compared with that in model group.ConclusionEarly alleviating brain edema,protecting brain tissue may be one of the mechanism of Chinese medicine to ameliorate the behavior deficits following TBI in rats. [
出处
《中国康复理论与实践》
CSCD
2005年第1期21-22,共2页
Chinese Journal of Rehabilitation Theory and Practice
关键词
创伤性脑损伤
脑疏宁
神经功能
大鼠
traumatic brain injury
Naoshuning
neurological function
rats
