摘要
目的 :比较早期肠道营养与早期静脉营养减轻内脏自由基损害的效应。 方法 :将 6 6只大鼠分成正常对照组、早期静脉营养组 (PN)、早期肠道营养组 (EN)。制成 30 %TBSA三度烧伤模型。分组灌喂或颈外静脉输液给予相同热量和热氮比的营养液。烧伤后 6、12、2 4、4 8、72h检测心、肝、肺、肾组织血管通透性、丙二醛 (MDA)、超氧化物歧化酶 (SOD)和组织含水量的变化。 结果 :烧伤后大鼠心、肝、肺、肾组织血管通透性、MDA和组织含水量均较对照组升高 ,EN组在多个时相点低于PN组 (P <0 .0 5 ,P <0 .0 1)。EN组组织SOD在多个时相点高于PN组 (P <0 .0 5 ,P <0 .0 1)。 结论 :早期肠道营养可减轻内脏水肿、血管通透性增高及氧自由基损害。
Objective:To investigate the effect of early enteral nutrition on free radical injury in burned rats. Methods:Wistar rats were randomly divided into early enteral nutrition (EN) group, early parenteral nutrition (PN) group and control (C) group. The EN and PN groups were inflicted with 30% TBSA full-thickness skin burns, EN group were fed by pouring Aolikang liquid into stomach, and PN group were fed by infusion of nutrition through the neck vein. The same carolies and protein were supplied to the two groups. Vascular permeability, water content, SOD and MDA in organ tissue were assessed. Results:The vascular permeability of heart, liver, lung, and kidney in EN and PN groups increased significantly than in C group (P<0.05-0.01). It was significantly higher in EN group than in PN group(P<0.05-0.01). The tissue water contents in four organs in EN and PN groups were higher than in C group (P<0.05-0.01), and they were obviously higher in PN group than in EN group (P<0.05).The levels of SOD in EN and PN groups were significantly decreased than in C group (P< 0.05 ), and in EN group it was higher than that in PN group (P<0.05). Compared with C group, the MDA contents in liver, lung and kidney tissue in EN and PN groups increased significantly (P<0.05-0.01), and it was lower in EN group than that in PN group (P< 0.05 ). Conclusions:Early Enteral nutrition can relieve free radical injury in burned rats.
出处
《肠外与肠内营养》
CAS
2005年第1期33-36,共4页
Parenteral & Enteral Nutrition
