摘要
目的 :探讨p5 3和MUC1蛋白表达与非小细胞肺癌 (non smallcelllungcancer ,NSCLC)发生、发展以及预后的关系。方法 :应用免疫组化ABC方法对 65例NSCLC中p5 3和MUC1表达水平进行研究 ,用Cox比例风险模型进行分析。结果 :肺癌MUC1表达率为 77% ( 5 0 /65 ) ,高表达率为 60 % ( 3 9/65 ) ,高表达NSCLC患者生存期明显小于低表达患者 ,P <0 0 5 ;p5 3表达率为 80 % ( 5 2 /65 ) ,高表达率为 60 % ( 3 9/65 ) ,高表达NSCLC患者生存期也小于低表达患者 ,但差异无统计学意义 ,P >0 0 5 ;经Cox比例风险模型回归分析显示 ,影响肺癌预后的前 4种因素依次为MUC1、TNM分期、淋巴结受侵情况及分化程度。结论 :p5 3与NSCLC发生有关 ,MUC1与NSCLC发生和发展有关 ,并可独立判断预后。
OBJECTIVE:To evaluate the expression levels of p53 and MUC1 protein in oncogenesis,development and prognosis of non-small cell lung cancer (NSCLC).METHODS: Immunohistochemical technique(ABC) was used to detect the expressions of p53 and MUC1 protein in 65 NSCLC samples. Multivariate analysis using cox’s proportional hazards model was preformed.RESULTS: The positive immunstaining rate of MUC1 was 77%(50/65) and the high expression rate 60%(39/65).The patients in the low-expression group obviously survived longer than those in high-expression group,and the difference was significant,P<0.05. The positive immunstaining rate p53 was 80%(52/65) and the high expression rate 60%(39/65).The patients in the low-expression group seemed to have longer survival time than those in the high expression group,but the difference was not significant,P>0.05.The COX proportional hazard regression moded revealed 4 important factors pertaining to patients survival rate as following:MUC1 expression level,TNM stages,lymph node metastasis and cell differentiation.CONCLUSIONS: p53 might be closely related to the occurrence of NSCLC.MUC1 was associated with the occurrence and development of NSCLC,and could evaluate independently the prognosis.[
出处
《肿瘤防治杂志》
2004年第7期694-696,共3页
China Journal of Cancer Prevention and Treatment
基金
河南省科委资助课题 ( 991170 2 3 0 )
