摘要
目的:探讨不同类型冠心病患者可溶性E-选择素(solubleE-selectin,SES)、C-反应蛋白(C-reactiveprotein,CRP)的变化及其临床意义。方法:81例患者,按临床诊断分为4组:急性心肌梗死组17例、不稳定型心绞痛组24例、稳定型心绞痛组20例和20例对照组患者(阵发性室上速)。分别检测各组患者SES及CRP的水平,对冠心病患者的冠状动脉损害行Gensini评分,并比较各组间的差异。对冠心病患者冠状动脉损害行Gensini评分,并与其SES及CRP水平进行直线相关分析。结果:①急性心肌梗死组、不稳定型心绞痛组及稳定型心绞痛组的SES犤其值分别为(99.29±15.04),(97.46±11.33),(78.48±18.93)μg/L犦及CRP犤其值分别为(6.73±1.44),(5.31±1.08),(4.13±1.11)mg/L犦的水平高于对照组犤SES为(62.76±8.23)μg/L,GRP为(3.28±0.67)mg/L犦。②急性心肌梗死组、不稳定型心绞痛组SES及CRP水平与稳定型心绞痛组相比,其值明显增加;急性心肌梗死组和不稳定型心绞痛组SES水平相近,急性心肌梗死组CRP高于不稳定型心绞痛组。③急性冠状动脉综合征(acutecoronaryinsufficiency,ACS)患者SES水平与冠状动脉Gensini评分呈正相关(r=0.682,P<0.01),CRP水平与冠状动脉Gensini评分不相关。结论:SES。
AIM:To investigate the changes and clinical significance of soluble E-selectin(SES) level and C-reactive protein(CRP) in patients with coronary heart disease(CAD) of different subtypes. METHODS:According to the clinical diagnosis, 81 patients were divided into 4 groups: acute myocardial infarction(AMI group, n=17),unstable angina group(UA group,n=24),stable angina group (SA group,n=20) and control group(patients with paroxysmal supraventricular tachycardia,n=20).Serum levels of SES and CRP were measured in all the groups,the severity of coronary lesion was graded with Gensini score in the CHD patients,and the differences among the groups were compared.Person correlation analysis test was used to analyze the relationships between Gensini score and the levels of SES and CRP in the CAD patients. RESULTS:①The serum levels of SES and CRP in the AMI group [(99.29±15.04) μg/L and (6.73±1.44) mg/L], UA group[(97.46±11.33) μg/L, (5.31±1.08) mg/L]and SA group[(78.48 ±18.93) μg/L, (4.13±1.11) mg/L]were higher than those in the control group[(62.76±8.23) μg/L, (3.28±0.67) mg/L].②Compared with SA group,the levels of SES and CRP were obviously elevated in the AMI group and UA group;there was no significant difference in the SES level between the AMI group and UA group, while the level of CRP in the AMI group was higher than that in the UA group.③In the patients with acute coronary insufficiency(ACS),the SES level was positively correlated with coronary arterial Gensini score(r=0.682,P< 0.01),while the CRP level had no relation with the Gensini score in ACS. CONCLUSION:SES and CRP can be used as the non-invasive markers of coronary plaque destabilization and the severity of CAD;The level of SES is positively correlated with the extent of coronary atherosclerosis in ACS patients.
出处
《中国临床康复》
CSCD
北大核心
2005年第3期52-53,共2页
Chinese Journal of Clinical Rehabilitation
