摘要
目的 探讨山莨菪碱对大鼠肝脏缺血损伤的保护作用及其机制。方法 测定大鼠肝脏缺血再灌注 (模型组 )和预防性应用山莨菪碱 (预防组 )时胆汁流量、肝组织丙二醛 (MDA)含量及肝脏组织学改变和中性粒细胞浸润程度。结果 预防组与模型组相比 ,胆汁流量显著增加 (P <0 0 1) ,MDA含量显著降低 (P <0 0 1) ,预防组肝脏组织学变化较轻 ,白细胞浸润较少。结论 山莨菪碱具有对肝脏缺血再灌注损伤明显的保护作用 。
Objective To study the effect of Anisodamine on hepatic ischemia-reperfusion injury and its possible mechanism in rats.Methods The bile flow, levels of malondiadehyde(MDA) in the hepatic tissues were measured in hepatic ischemia-reperfusion injury in rats with or without administration of Anisodamine. The histological changes in hepatic tissues and the degree of neutrophil infiltration were also measured. Results As the liver reperfusion prolonged, the neutrophil infiltration degree was increasing. After administration of Anisodamine intravenously, the liver tissue MDA and the degree of neutrophil infiltration were significantly lower than those of untreated groups( P <0 01).But the bile flow was significantly higher than that of untreated groups( P <0 01).Conclusions The hepatic ischemia-reperfusion injury can be significantly protected with Anisodamine. The protective mechanism may be that Anisodamine inhibits the production of oxygen-derived free redicals. [
出处
《中国急救医学》
CAS
CSCD
北大核心
2001年第1期4-5,共2页
Chinese Journal of Critical Care Medicine
关键词
肝脏
缺血再灌注损伤
山莨菪碱
Liver
Ischemia-reperfusion injury
Anisodamine
