摘要
目的:研究N cadherin(神经性钙黏附分子)在非 小细胞肺癌组织中的表达及临床生物学意义.方法:常规石 蜡包埋切片行免疫组织化学检测90例非小细胞肺癌组织中 N cadherin的表达.结果:90例非小细胞肺癌组织中N cad herin表达阳性的例数为30例(33.3%);34例Ⅲ期患者中N cadherin阳性率47.06%,56例Ⅰ、Ⅱ期患者中N cadherin阳 性率25%,差异具有显著性意义(P<0.05).有淋巴结转移 的患者中N cadherin阳性率42.31%,无淋巴结转移的患者中 N-cadherin阳性率21.05%,差异具有显著性意义(P< 0.05).N cadherin在肺腺癌和鳞癌中的表达无显著性差异 (P>0.05).N cadherin在非小细胞肺癌组织中的表达与其分 期、淋巴结转移有关.结论:N cadherin可能参与非小细胞肺 癌侵袭和转移.
AIM: To explore the expression level of N-cadherin gene in patients with primary non-small cell lung cancer (NSCLC). METHODS: The expression of N-cadherin protein was detected in 90 NSCLC tissues by immunohistochemistry. RESULTS: The positive rate of N-cadherin expression in NSCLC tissues was 33.3%(30/90). No significant difference of N-cadherin expression was found in NSCLC tissues of squamous cell carcinoma (30%) and adenocarcinoma (35%)(P>0.05). The positive rate of N-cadherin expression (47.06%) in the NSCLC tissues of Ⅲ stage was significantly higher than that in NSCLC tissues ofⅠandⅡstages (25%) (P<0.05). The positive rate of N-cadherin expression (42.31%) in the NSCLC tissues of N 1, 2 and 3 groups was significantly higher than that in the NSCLC tissues of N 0 group (21.05%) (P<0.05). N-cadherin expression rate was related to the lymph node metastasis (P<0.05) and TNM stages of lung cancer (P<0.05), but not to the histological classification. CONCLUSION: N-cadherin protein expression may be associated with the invasion and progression of NSCLC.
出处
《第四军医大学学报》
北大核心
2005年第2期157-159,共3页
Journal of the Fourth Military Medical University
