摘要
目的 观察老年急性脑梗死患者血浆内皮素 (ET)、降钙素基因相关肽 (CGRP)及心钠素 (ANP)含量的动态变化及其在老年急性脑梗死过程中的病理作用。方法 用放射免疫技术测定 78例老年急性脑梗死患者 (脑梗死组 )和 6 0名健康老人 (对照组 )的血浆ET、CGRP和ANP水平 ,并观察其动态变化。结果 (1)脑梗死组病程各期血浆ET、ANP含量均较对照组明显升高 (P <0 0 5～ 0 0 1) ,且随时间延长有逐渐降低的趋势 ;CGRP的水平则明显低于对照组 (P <0 0 5 )。 (2 )与腔隙脑梗死组比较 ,大面积及小面积脑梗死组血浆ET及ANP水平均明显升高 (均P <0 0 1) ,而其CGRP水平则显著降低 (P <0 0 5 )。结论 ET、CGRP和ANP与老年急性脑梗死的发生、发展密切相关 ;ET与CGRP之间和ET与ANP之间存在相互促进。
Objective To determine the dynamic changes of plasma endothelin (ET), calcitonin gene related peptide (CGRP) and atial natriuretic peptide (ANP) in elderly patients with acute cerebral infarction and explore the pathological role of ET, CGRP and ANP in the development of acute cerebral infarction.Methods The concentrations of ET, CGRP and ANP in plasma were determined with radioimmunoassay in 78 elderly patients with acute cerebral infarction and 60 normal controls.Results (1)The levels of ET and ANP in patient group were significantly higher than those in control group ( P<0.05～0.01), and those levels were gradually declined with the duration of disease. But the concentration of CGRP in patient group was lower than that in control group ( P<0.05).(2)Compared with lacunar infarct group, the concentrations of ET and ANP in large area infarct group (>3 cm) and small area infarct group (1.5～3.0 cm) were significantly higher (all P<0.01), but the level of CGRP was lower( P<0.05).Conclusions ET, CGRP and ANP play important roles in the development of brain injury in elderly acute cerebral infarction. There have close relationship of facilitation and inhibition in the pathogenesis of elderly acute cerebral infarction.
出处
《临床神经病学杂志》
CAS
2004年第6期408-410,共3页
Journal of Clinical Neurology
关键词
急性脑梗死
内皮素
降钙素基因相关肽
心钠素
acute cerebral infarction
endothelin
calcitonin gene related peptide
trial natriuretic peptide
