摘要
[目的]观察猴免疫缺陷病毒(SIV)感染猕猴后循环免疫复合物(CIC)的动态变化。[方法]使用SIVmac251感染30只实验猴,并在感染SIV后不同时间点取样,采用补体致敏的酵母菌凝集试验,检测血清CIC水平的变化,并同时检测了68只正常猴的血清作为对照。[结果]30只SIV感染猴在接种后第4周开始检出CIC(总阳性率为30％),第8周迅速升高并达到高峰46.7％,在第16周降低至33.3％并逐渐下降;从第20周开始,感染猴的CIC浓度维持一较低的滴度和阳性率,接近于正常猴(约10％)。[结论]CIC在SIV急性感染期间出现并升高,但其后伴随着循环中病毒的减少,CIC也逐渐下降。CIC的形成可能无益于控制病毒复制和引导抗病毒免疫,并可能参与了SIV感染后的发病过程。
[Objective] To observe the dynamic changes of circulating immune complex (CIC) in monkeys infected by simian immunodeficiency virus (SIV). [Methods] Agglutination test of complement-sensitized yeast cell was used to determine the serum CIC level in 30 cases of monkeys, which were infected with SIVmac251 and sampled in different time-points after infection. Sixty-eight cases of normal monkeys were also examined as controls. [Results] After SIV infection, CIC can't be detected in all 30 monkeys until the 4th week, the total positive rate being 30% . In the 8th week, CIC were detected in 46.7% of these monkeys and then declined gradually in the following 12 weeks. Since the 20th week, the CIC in these monkeys maintained lower liter and lower positive rate which was close to that of the normal monkeys (about 10%). [Conclusion] CIC appeared and increased during the primary SIV infection and declined accompanying with the virus clearance from the circulalion. The formation of CIC may not benefit to the control of virus replication and the induction of anti-virus immunity; CIC has a role in the pathogenesis after SIV infection.
出处
《广州中医药大学学报》
CAS
2005年第1期7-9,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省科技计划资助项目(编号:B304)
关键词
猴获得性免疫缺陷综合征
抗原抗体复合物
疾病模型
动物
恒河猴
成束猴
SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME
ANTIGEN-ANTIBODY COMPLEX
DISEASE MODELS, ANIMAL
MACACA MULATTA
MACACA FASCICULARIS
