摘要
目的 探讨慢性肝炎患者肝纤维化指标 [血清透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )、Ⅳ型胶原 (CⅣ )、层黏蛋白 (LN) ]的诊断价值。方法 对 16 0例不同程度慢性肝炎患者的血清肝纤维化指标 :HA、PCⅢ、CⅣ、LN ,采用放射免疫法进行检测和比较 ,分析它们与临床诊断之间的关系。结果 4项指标在慢性肝炎轻、中、重度的检测值均明显高于正常人组 (P <0 .0 1) ,轻度组与正常组的LN数值有很大的重叠 ,中、重度组的HA检测数值远大于轻度及正常组的检测数值。结论 血清HA、PCⅢ、CⅣ、LN检测能很好地反映肝纤维化活动程度 ,HA在反映肝损害程度方面具有明显优势 ,但LN作为早期指标并不利于临床判断。
Objective To evaluate the diagnostic value of serum markers of hepatic fibrosis in patients with chronic hepatitis. Methods Serum levels of HA,PCⅢ,CⅣand LN were detected by using radioimmunoassay (RIA)in patients with different grade chronic hepatitis. The relation between markers and clinical diagnosis could be found by analysis of these data. Results Serum levels of the four markers in patients with different grade chronic hepatitis were all much higher than those in normal group (P<0.01). There was a great overlap between mild chronic hepatitis and normal groups. Serum marker levels in median chronic hepatitis group and severe chronic hepatitis group were significantly higher than those in mild chronic hepatitis and normal groups. Conclusion Serum fibrosis markers could reflect the activity of hepatic fibrogenesis fairly well. HA is the best selected marker in reflecting hepatic injury. LN, as an early marker, is unsuitable for clinical diagnosis.
出处
《山西医科大学学报》
CAS
2004年第6期586-587,共2页
Journal of Shanxi Medical University
关键词
肝炎
慢性
肝硬化
放射免疫测定
hepatitis,chronic
radioimmunoassay
liver cirrhosis
