摘要
目的探讨军人创伤后应激障碍(PTSD)与适应障碍(AD)患者事件相关电位P300的变异特点。方法对33例PTSD和34例AD患者以及30名健康军人(对照组),使用美国NicoletBravo脑电生理仪,以听觉靶刺激和非靶刺激序列为诱发事件运用oddball模式完成P300检测。结果三组CZ脑区P3与PZ脑区N2靶潜伏期,以及PZ脑区P3靶波幅和CZ脑区P2非靶波幅的差异有显著性(P<0.05,0.01);PTSD组CZ脑区P3与PZ脑区N2靶潜伏期延迟或前移,与对照组和AD组的差异有显著性(P<0.01);PTSD组PZ脑区P3靶波幅和CZ脑区P2非靶波幅均降低,与对照组及AD组的差异有显著性(P<0.05,0.01)。结论P300作为反映PTSD认知功能障碍的客观生理指标,可作为PTSD辅助诊断的一个脑电生理学标志。
Objective To investigate the changes of event related potentials P300 in patients with post-traumatic stress disorder (PTSD) and adjustment disorder (AD). Methods An 'oddball' paradigm was used to elicit the auditory P300 from 33 patients diagnosed as having PTSD according to CCMD-3, 34 patients with AD and 30 normal controls, by using a Nicolet Bravo Instrument.Results A significant difference of P300 among three subject groups was found with both latencies (PZ/N2,CZ/P3) and amplitudes (CZ/P2, PZ/P3). Compared with the control group and the AD group, PTSD patients showed prolonged PZ/N2 latency (P<0.01) and shorten CZ/P3 latency (P<0.01). Compared with the control group and the AD group, PTSD patients showed decreased PZ/P3 amplitude from target and CZ/P2 amplitude from non-target (P<0.01). Conclusion Auditory P300 could be served as a physiological index in the reflection of the cognitive disorder in PTSD.
出处
《实用医药杂志》
2004年第10期914-915,918,共3页
Practical Journal of Medicine & Pharmacy
基金
济南军区医药卫生计划课题(编号03j036)
