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军人心理创伤后应激障碍患者与健康军人事件相关电位的对照研究 被引量:7

A Comparative Study of Event-related Potentials in Patients with Post-traumatic Stress Disorder.
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摘要 目的 探讨军人心理创伤后应激障碍 ( PTSD)患者 3种事件相关电位 ( ERP)的变异。方法 应用美国 Nicolet Bravo脑诱发电位仪 ,采用光和声成对刺激、反应时间以及听觉靶 -非靶刺激序列技术 ,检测 66例 PTSD和 3 6名正常人 ( NC)的关联性负变 ( CNV)、P30 0 、以及失配性负波 ( MMN)。结果  1 CNV:M1 潜伏期 PTSD组 [( 5 0 3 .4± 1 3 9.2 ) ms]长于 NC组[( 4 2 0 .1± 1 2 3 .6) ms;P<0 .0 1 ],M2 波幅 PTSD组 [( 1 8.9± 7.9) μv]高于 NC组 [( 1 1 .7± 5 .8) μv;P<0 .0 1 ],指令信号后负变化 ( PINV)的出现率 PTSD组 ( 3 9% )高于 NC组 ( 3 % ;P<0 .0 1 )。 2 P30 0 :在靶刺激中 ,Cz脑区的 P3潜伏期 PTSD组[( 3 1 5 .4± 1 7.8) ms]短于 NC组 [( 3 3 6.7± 1 5 .5 ) ms;P<0 .0 1 ],Pz脑区的 N2 潜伏期 PTSD组 [( 2 78.5± 2 1 .8) ms]长于 NC组 [( 2 63 .4± 1 4.2 ) ms;P<0 .0 1 ],Pz脑区的 P3波幅 PTSD组 [( 3 .4± 1 .8) μv]低于 NC组 [( 5 .9± 2 .4) μv;P<0 .0 1 ]。在非靶刺激中 ,Cz脑区的 P2 波幅 PTSD组 [( 2 .5± 1 .4) μv]低于 NC组 [( 3 .4± 0 .1 ) μv;P<0 .0 1 ]。 3 MMN:潜伏期 PTSD组[( 2 1 4.2± 2 5 .7) ms]长于 NC组 [( 1 93 .7± 2 2 .6) ms;P<0 .0 1 ],波幅 PTSD组 [( 8. Objective To investigate the variations of contingent negative variation(CNV),P 300 ,and mismatch negative(MMN)in aptients with post-traumatic stress disorder(PTSD).Methods 66 cases of patients with PTSD and 36 normal controls(NC)were involved.The event-related potentials(ERP)CNV,P 300 ,and MMN were recorded with Nicolet Bravo Instrument.Results Compared with NC group,PTSD group showed delayed M 1 latency and increased M 2 amplitude(P<0.01).The PINV emergence rate of CNV in PTSD group was significant different from NC group(P<0.01).And a significant difference of ERP-P 300 among two subject groups was found with both latencies(Pz/N 2,Cz/P 3),P 3 amplitude from target and P 2 amplitude from nontarget(P<0.01).Compared with NC group,PTSD group showed further prolonged MMN latency and higher increased MMN amplitude(P<0.01).Conclusion The characteristics of ERP could served as a physiological index in diagnosis of PTSD.
机构地区 中国.解放军第
出处 《中国健康心理学杂志》 2004年第4期244-246,共3页 China Journal of Health Psychology
基金 济南军区医药卫生计划课题 编号 :0 3 j0 3 6
关键词 军人 心理创伤 应激障碍 健康军人 事件相关电位 对照研究 Post-traumatic stress disorder Event-related potentials Contingent negative variation P 300 Mismatch negativity
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