摘要
目的:评价肾脏病理在预测小儿狼疮性肾炎(LN)预后中的意义。方法:对确诊为LN的42例患儿进行肾活检,并予病理分型和活动性指数(AI)及慢性指数(CI)评分。对AI及CI分值分别以预后好和预后差行单元回归分析。结果:Ⅱ型10例(24％),Ⅲ型5例(12％),Ⅳ型24例(57％),Ⅴ型3例(7％);发生肾衰竭14例(33％),其中Ⅳ型12例(86％),Ⅱ型和Ⅲ型各1例。预后好组AI=1.54±2.03,CI=0.67±0.47;预后差组AI=7.17±0.85,CI=3.33±2.99;单因素回归计算AI与预后的关系:Y=1.11-0.129_x,r=-0.857.857,P<0.01,有显著性差异;CI与预后的关系:Y=0.766-0.108_x,r=-0.805,P<0.01,亦有显著性差异。结论:通过肾活检并进行AI和CI评分予评估小儿LN的预后,具有重要的临床意义。分值越高,预后越差。
Objective: To study the relationship the pathological change with the prognosis in children with lupus nephritis(LN). Methods: To classify the pathological types and score of the active index(AI) and chronic index(CI) by renal biopsies. 42 patients have been diagnosed as LN and the sing/e regression analysis was proceeded between the scores of Aland CI with their prognosis. Results: 10 cases (24% ) were type Ⅱ , 5 cases (12% ) were type Ⅲ ,24 cases (57% ) were typeⅣ, 3 cases(7%) were type Ⅴof LN pathologicall feature. 14 patients suffer from renal failure. Among these cases, there were 12 cases (86%) were type IIIVVV and 1 case was type Ⅲ and type V respectively. In the group of good prognosis AI was 1.54 ± 2.03, CI was 0.67± 0.47. In the group of bad prognosis AI was 7.17 ± 0.85, CI was 3.33± 2.99, The relationship between single regression estimation AI and prognosis: Y was 1.11 - 0.129X, r= - 0.857, P< 0.01,there is an significantly difference. The relationship between CI and prognosis: Y was 0.766 - 0.108X, r= -0.805, P<0.01, there is also a difference.Conclusion; With renal biopsy to score the AI and CI to evaluate the prognosis of LN has very important clinical significance. The higher the scores of AI of CI is, the worse prognosis certainly would be.
出处
《中国中西医结合肾病杂志》
2000年第4期209-211,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
